具有双重作用机理的可聚合抗菌单体的合成与应用
关键词 双重抗菌 两性离子水凝胶 抗细菌黏附性能 杀菌性能
Title Preparation and application of polymerizable antibacterial
monomer with dual antibacterial action
Abstract
In this paper ,A kind of both prevent bacterial adhesion and sterilization performance
zwitterionic monomer was synthesized. With salicylic acid as initial raw materials, with
bromoacetyl bromide as the acylating reagent complete acylation of salicylic acid on
hydroxyl oxygen. Again with tertiary butyl alcohol with the first step carboxyl acid of
salicylic acid derivatives form esterification reaction to protect the carboxyl. Then use
carbon-carbon double bond of tertiary amine and the halogenated hydrocarbon forming
nucleophilic substitution reaction and generating quaternary ammonium salt type
zwitterionic monomer. Use hydrochloric acid catalyze the hydrolysis of ester bond to
make the original salicylic acid on the carboxyl freed. Finally a hydrolyzable ester
linkages with antibacterial leaving group comprising salicylic acid SA coupling
carboxy betaine zwitterionic units was synthesized. The monomer contains an
unsaturated double bond that allows it to polymerize by chemical initiation, The
monomer was made to zwitterionic hydrogel. The obtained monomer was
characterized by 1
H-NMR and FTIR spectra. The antimicrobial activity of the hydrogel
was investigated against both E.coli and S.aureus. The hydrogel killed above 99.1% E.
coli and above 98.2% S. aureus after contact 9 h. And the antifouling efficacy was
investigated against E.coli which contained the fluorescent protein. Compared to the
samples, the hydrogel exhibited excellent antifouling and antimicrobial properties.
Through comparing anti-adhesion properties and antibacterial effect, it indicate the
hydrogel have more excellent and long-lasting anti-adhesion and sterilization effect.
Keywords dual antibacterial action, zwitterionic hydrogel, non-fouling, antimicrobial
目 次
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