1,4,7,10-四氮杂环十二烷的合成
毕业论文关键词：大环多胺， 配合物，1,4,7,10-四氮杂环十二烷
The synthesis of 1,4,7,10-Tetraazacyclododecane(cyclen)
Abstract: Macrocyclic polyamine class of compounds and their complexes of extensive role, in recent years, for their research has become one of the emerging issues in the field of study.Due to the unique spatial structure and excellent coordination ability of macrocyclic poyamines, it can coordinate with mrtal ions, organic cations, organic anions, neutral molecules, so it is excellent coordination abilityligands. Therefore it can form a variety of coordination complex, and have extensive use of these complexes in the emerging field of molecular recognition, artificial enzyme, and medical diagnosis, etc. But synthesis of cyclen and its derivatives is rather difficult. This paper introduces the preparation methods of cyclen, such as Stetter method, Richman-Atkins method, Weisman method, Glyoxal condensation reaction. And then ,various synthetic methods for synthesizing these compounds are summarized. Then, studied one of the synthesis of cyclen method and discuss the result.
Key words: macrocyclic polyamines, coordination complex, 1,4,7,10-Tetraazacyclododeca
目录
1 绪论 1
1.1 背景介绍及用途 1
1.2 大环多胺及其配合物的合成进展 2
1.3 1,4,7,10-四氮杂环十二烷的合成方法 3
1.3.1 stetter合成法 3
1.3.2 richman-atkins合成法 3
1.3.3 weisman合成法 5
1.3.4 乙二醛缩合法 5
1.3.5 其他方法 7
1.4 1,4,7,10-四氮杂环十二烷的简介 8
1.5 1,4,7,10-四氮杂环十二烷的物化参数 9
2 实验部分 10
2.1 试剂与仪器 10
2.1.1 试剂 10
2.1.2 实验设备 10
2.2 1,4,7,10-四氮杂十二烷的合成方法 11
2.2.1 线性TETA的制备 12
2.2.2 中间体1,1-二亚乙基双-2-咪唑啉的合成 12
2.2.3 扩环反应 12
2.2.4 水解反应 13
2.2.5 重结晶 13
2.3 检测实验 13
2.3.1 核磁共振 13
2.3.2 质谱分析 13
2.3.3 气相色谱分析 14
3 结果与讨论 16
3.1 线性TETA的制备 16
3.2 中间体1,1-亚乙基双-2-咪唑啉的制备 18
3.3 扩环反应 19
3.4 水解反应 20
4 结论 23
致谢 26
参考文献 27
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