天然维C胶囊的制备研究及表征
毕业论文关键词：多重乳液法；壳聚糖；文生素C；微胶囊
Study on the preparation of a kind of natural vitamin C capsules
Abstract：In this paper, the natural VitaminC capsules were prepared through multiple emulsion polymerization method using chitosan as wall materials and Vitamin C solution as core materials.The optimum preparation conditions were obtained by investigating the influence of emulsifier, emulsification method,the ratio of core to wall and other single factors.The microscope observe its morphology, the fourier transform infrared spectrum (FTIR) analysis its constituents, thermogravimetricanalysis (TGA) measure its coating rate and ultraviolet spectroscopy measure its slow-release property.The optimum preparation conditions were determined: m(inner emulsifier: Span-80) is 4%,m(soybean oil):m(vc solution)=2:1, mixing and homogenizing to prepare the inner emulsion, m(tween-20)is 3%,m(outer water phase):m(inner emulsion)=2:1,w(chitosan solution) is 1.5%, using CaCl2 as curing agent and mixing 15minute. The particle diameter is 84μm.The coating rate is 5.248%.FTIR spectrum shows that absorption peaks of oxhydryl group appear at 3404cm-1,1107cm-1 and absorption peak of ester C-O bond appears at 1737cm-1,which means the successful encapsulation of Vitamin C solution.Through ultraviolet spectroscopy results show that natural vitamin C capsule in aqueous solution and simulated gastric fluid, vitamin C contents increased with time and slowlyincrease, indicating some slow-release property.
Keywords: Multiple emulsion polymerization; Chitosan; Vitamin C; Microcapsule
目录
1 绪论 1
1.1 微胶囊技术概念 1
1.2 微胶囊的制备方式 1
1.2.1 喷雾干燥法 1
1.2.2 乳液聚合法 2
1.2.3 界面聚合法 2
1.2.4 复相乳液法 3
1.3 文生素C微囊的研究现状 3
1.3.1 文生素C的性质与应用 3
1.3.2 包埋材料 3
1.3.3 包埋方法 4
1.4 本课题的研究目的和意义 5
2 实验部分 7
2.1 实验材料 7
2.1.1 实验材料和试剂 7
2.1.2 主要仪器设备 7
2.2 天然文C胶囊的制备工艺研究 8
2.2.1 内乳液（W/O）的制备 8
2.2.2 天然文C胶囊的制备工艺探究 8
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