碳酸钙纳米结构材料的药物传输性能研究
毕业论文关键词：碳酸钙；球霰石；载药；释放
Drug transmission performance research on calcium carbonate nanostructure materials
Abstract：As a typical mineral inorganic material, calcium carbonate is widely used in medical, environmental and industrial. Calcium carbonate has three polycrystalline structure：Calcite, Aragonite and Vaterite. For the characteristic of small density, large specific surface area, good security and lower price, the researches on preparation and properties of calcium carbonate polymer composites are high-profile, especially spherical Vaterite. Vaterite is easily used to make other materials because of the poor stability, which are quite popular and widely used. Drug transmission performance research on calcium carbonate nanostructure materials was studied in the paper. According to the different methods of reaction temperature, reaction means and whether to add high molecular materials, Vaterite has been made with different morphology and specific surface area. Properties can be confirmed by all kinds of advanced testing instruments, for example, XRD, BET, etc. Finally, the various morphology Vaterite was applied to medicine carrying and drug release to review its application prospect in medicine.
Key Words：Calcium carbonate；Vaterite；Medicine carrying；Drug release
目 录
1 研究背景 1
1.1 碳酸钙药物的研究意义及简介 1
1.2 Vaterite的制备方法 1
1.2.1 半连续实验法 1
1.2.2 加入表面活性剂法 2
1.2.3气相沉积法 3
1.2.4模板法 3
1.3纳米CaCO3的应用 4
1.3.1 SiO2空心微球的制备 4
1.3.2合成纳米羟基磷灰石(HA)作为药物载体 4
1.3.3制备雷公藤红素缓释固体分散体 5
1.3.4复合材料的制备 5
1.3.5纳米CaCO3肠溶生物黏附片(NCaEBT)的制备 5
1.4 本课题研究的意义及思路 6
2 实验流程 7
2.1 合成Vaterite及研究其药物传输性流程 7
3 实验与材料 7
3.1 实验材料 7
3.1.1 主要试剂 7
3.1.2 主要仪器 8
3.2 实验与讨论 8
3.2.1 不加高分子材料PSS 9
3.2.2 加高分子材料PSS（聚苯乙烯磺酸钠，Mw=70000，ppm=10000） 11
3.2.3 XRD的测定 11
3.2.4扫描电镜(SEM)检测 23
3.2.5 BET检测 26
3.2.6 载药实验 27
3.2.7 药物解析附实验 28
4 总结与展望 30
致谢 31
参考文献 32