扑热息痛片的制备和质量检测
对乙酰氨基酚也叫扑热息痛，在医学上，用于发热、风湿痛、头痛、神经痛及痛经等，一些对阿司匹林有强烈过敏反应的患者可以使用该药物。这种药物在水中很不稳定，而且大部分都不能溶于水。
本篇论文采用正交实验的方法，对扑热息痛分散片的处方进行设计，筛选出最优的设计处方，再对制备的分散片进行质量检测。有时患者需要一些特殊的用药需求，扑热息痛分散片正好可以满足其条件，适合于工业上的大规模生产。
毕业论文关键词：对乙酰氨基酚；分散片；正交试验；处方设计；质量检测
Preparation and Quality inspection of paracetamoltablets
Abstract:Dispersible tabletisrapidly disintegratingandtablets can be dispersed in water. Dispersible tabletscan quickly release drugs so as to improve the bioavailability of durgs.In addition,it has the advantages of easyproduction,easy and so on.Usually the dispersible tablet disintegration time,suspension or disper sionuniformity and solubility test.Tablet disintegrating agent are sodium carboxymethyl starch (CMS-Na), cross-linked polyvinylpyrrolidone (PVPP), croscarmellose sodium (CCNa), low substituted carboxymethyl cellulose (L-HPC).Quality inspection items of dispersible tablets are disintegration, solubility test, dispersible uniformity inspection.
Paracetamol(Acetaminophen)is used for fever,headache,rheumatic pain,nerve pain and dysmenorrhea and otherclinical,suitable for patients who are allergic to aspirin.Because the drug solubility in water and in aqueous solution with smaller stability problems, at the same time the drug absorption drug blood reached the peak at 10 -- 60min. The dispersion process prescription tablets paracetamol and inspect the quality of screening by orthogonal experim desin,the research Paracetamol Dispersible Tablets can meet the special need for medication, and provide a theoretical basis for industrial production.
KeyWords:Acetaminophen; Disket; Orthogonal test; preformulation; Quality inspection
目 录
1 研究背景 1
1.1扑热息痛片的制备研究的意义 1
1.1.1扑热息痛片的适用病症 1
1.1.2扑热息痛片的药理毒理 1
1.1.3扑热息痛片在其它治疗领域的研究开发 2
1.2片剂的制备和工艺选择 2
1.3扑热息痛的片剂制备 3
1.3.1扑热息痛片剂制备的种类及应用 3
1.4本课题研究的意义及思路 6
1.4.1分散片的发展现状 6
1.4.2分散片特点 6
1.4.3分散片速崩机理 7
1.4.4已开发的分散片种类 7
1.4.5分散片临床应用效果 8
1.4.6分散片的处方设计 8
1.4.7分散片的制备工艺 9
1.4.8扑热息痛分散片的制备和质量检测方法 9
2 实验材料和方法 9
2.1实验材料 9
2.1.1基本物质对乙酰氨基酚 9
2.1.2主要试剂 9
2.1.3主要仪器 10
2.2药物处方设计 10
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