摘要:纳米材料药物载体拥有小粒径，比较轻松穿透血-脑屏蔽，在生物有机体内容易降解的特点。磁性材料的药物载体可利用外部磁场被固定于肿瘤部位, 释放药物, 杀伤肿瘤细胞, 既可减少用药剂量, 又能避免伤害正常细胞, 可达到减轻药物毒副作用, 加速和提高治疗效果。如今将磁性材料和纳米技术两者相结合即磁性纳米材料的研究已经成为新型生物材料的研究热点。本实验中以纳米SiO2为核心包裹Fe3O4并以水热碱法刻蚀得到Fe3O4中空球，通过对咖啡酸苯乙酯的吸附与释放研究其载药与缓释性能。43281

毕业论文关键词： 纳米Fe3O4中空球；缓释；咖啡酸苯乙酯；磁性纳米材料

Preparation and slow release study Fe3O4 hollow nanospheres

Abstract:  Nanomaterials pharmaceutical carrier has a small size, more easily penetrate the blood - brain barrier, the advantage of easily degradable in the body. Pharmaceutical carriers magnetic material may utilize an external magnetic field is fixed to the tumor site, the release of drugs to kill tumor cells, can reduce the dosage, but also to avoid harming normal cells, can be achieved to reduce the side effects of drugs, acceleration and improve treatment. Today, both the technology and nano-magnetic material that is a combination of magnetic nanomaterials research has become a hot topic of new biomaterials. In this experiment nano Fe3O4 and Sio2 core package are etched with hot alkaline water Fe3O4 hollow sphere, through study of the adsorption and release of caffeic acid phenethyl ester of drug loading and release properties.

Key Words: nano Fe3O4 hollow spheres; sustained; caffeic acid phenethyl ester; magnetic nanomaterials

 目录 1

1.1课题来源及背景、研究目的 5

1.2理论意义和实际应用价值 7

2文献综述 8

2.1缓释剂的概念 8

    2.1.1.缓控释剂的定义 8

    2.1.2.缓控释剂的种类 8

            2.2 常见的几种释放技术 8

    2.2.1　定速释放技术 8

    2.2.2　定位释放技术 8

    2.2.3　定时释放技术 8

2.3. 药物缓释体系概述 9

2.4. 中空微球的制备方法 9

    2.4.1 模板法 9

    2.4.2硬模板法 9

    2.4.3软模板法 10

    2.4.4  奥斯特瓦尔德熟化法（Ostwald ripening） 10

    2.4.5  喷雾干燥法 10

2.5纳米药物载体的特性 10

3实验部分 14

3.1试剂及仪器 15

3.1.1试剂 15

3.1.2仪器 15

3.2实验方法 16

3.2.1 单分散SiO2纳米颗粒的制备 16

3.2.2 Fe3O4的包裹 18

3.2.3 SiO2的刻蚀 19

3.2.4 Fe3O4载药性能的测试