掺杂TiO2可降解聚合物纤维的制备及其抗菌性能研究
毕业论文关键词： 聚乳酸；静电纺丝；SEM；拉伸强度；抗菌性能
Preparation and antibacterial properties of Poly(lactic acid)/ TiO2 biodegradable nanofibers
Abstract
In this experiment, the polylactic acid (PLA) antibacterials nanofibers were fabricated via electrospinning procedure with dichloromethane and N, N-dimethylformamide as solvent, nano- TiO2 (35nm) as the antimicrobial. In order to enhance the suspension and well-distribution of nano- TiO2 into the PLA solvent, the suspension assay was carried out in advance. The microstructure of TiO2/PLA nano-fibers was observed by scanning electron microscopy, the hydrophilicity of the fibers was mearsured by contact angle machine. The mechanical properties were determined by a universal test machine. The MTT assay was employed to investigate the cytotoxicity of the nanofibers and the bacterial inhibition ring test was used to determine antibacterial effect of the products. Through the above tests, we finally found that the so-spun PLA nanofibers doped with nano- TiO2 were safe to cells and provided the antibacterial properties with smooth and uniform microstructure.
KeyWords: Polylactic acid; Electrostatic spinning；SEM；Tensile strength；Antibacterial properties
目 录
1. 绪论 1
1.1人工皮肤 1
1.1.1人工皮肤的发展 1
1.1.2人工皮肤材料研究的发展趋势 2
1.1.3 人工皮肤材料的选择 2
1.2静电纺丝 3
1.2.1 静电纺丝技术的起源 3
1.2.2静电纺丝技术的原理 4
1.2.3影响静电纺丝技术的因素 4
1.2.4静电纺丝技术现状 5
1.2.5静电纺丝技术的应用 5
1.2.6静电纺丝技术的发展方向 6
1.3 电纺丝薄膜的抗菌性能 7
1.3.1 纳米TiO2的物理性质 7
1.3.2 纳米TiO2的抗菌机理 8
1.4本次课题研究的目的和意义 8
1.5本次课题研究的主要内容 8
① 纳米TiO2悬浮稳定性的研究 8
② PLA/ TiO2可降解聚合物复合纤文膜的制备 9
③ PLA/ TiO2可降解聚合物复合纤文膜的微观形貌 9
④ PLA/ TiO2可降解聚合物复合纤文膜的亲水性 9
⑤ PLA/TiO2可降解聚合物复合纤文膜的力学性能研究 9
⑥ PLA/ TiO2可降解聚合物复合纤文膜的细胞毒性研究 9
⑦ PLA/TiO2可降解聚合物复合纤文膜的抗菌性能研究 9
2、实验部分 10
2.1实验原料 10
2.2 主要仪器和设备 10
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