乙酰胺类化合物的合成+文献综述
毕业论文关键词： 氯乙酸甲酯；苯酚；对氯苯酚；二甲胺；甲胺；N-甲基-2-（苯氧基）乙酰胺
Synthesis of acetyl amine compound
Abstract: Chloroacetic acid methyl ester as the starting material, anhydrous potassium carbonate in the presence of a catalyst, N, N- dimethylformamide (DMF) as solvent, with various phenolic compounds, intermediates phenoxyacetate (Ⅰ); Furthermore, intermediate (Ⅰ) is reacted with various amines to give the product aryloxy acetamides. Also paper also examines the reaction temperature, reaction time, material feed ratio on the first step of the product (Ⅰ) and the yield of the second step, in order to determine the conditions were as follows: reaction temperature 80 ℃, reaction time 4.0h, material feed ratio of n (acid methyl ester): n (phenol) = 1.0: 1.2. Under this condition, the first step in the product (Ⅰ) the yield of 75% or more. Reaction temperature: 40 ℃, reaction time 4.0h, material feed ratio n (phenoxyacetate): n (dimethylamine) = 1.0: 2.0. Step product yields (Ⅱ) yield of over 70%; reaction temperature: 30 ℃, reaction time 4.0h, material feed ratio n (phenoxyacetate): n (trimethylamine) = 1.0: 2.5. Step product yields (Ⅲ) yield of over 70%.
Keywords: acid ester; phenol; p-chlorophenol; dimethlamine; trimethylamine; N-methyl-2-(phenoxy) acetamide
目录
1 前言 1
1.1 课题的目的和意义 1
1.2 国内外研究现状与水平 2
1.3 我国农药行业存在的问题 3
1.3.1 药剂自身的毒性问题 3
1.3.2 “三废”和杂质问题 3
1.3.3 光学体合成问题 3
1.4 文献查阅、调研情况 4
1.4.1 乙酰胺类的性质 4
1.4.2 乙酰胺类的分类 4
1.5 乙酰胺类的制备方法 7
1.5.1 方法一 7
1.5.2 方法二 7
1.5.3 方法三 7
1.5.4 研究内容 8
2 实验部分 9
2.1 实验的仪器和试剂 9
2.1.1 实验仪器 9
2.1.2 试剂及其物性常数 10
2.2产物的制备 10
2.2.1 苯氧乙酸甲酯的制备 10
2.2.2 N,N-二甲基-2-(苯氧基)乙酰胺的制备 10
2.2.3 N -甲基-2-(苯氧基)乙酰胺的制备 11
2.2.4 2-(4-氯苯氧基)乙酸甲酯的制备 11
2.2.5 N,N-二甲基-2-(4-氯苯氧基)乙酰胺的制备 11
3 结果与讨论 12
3.1 苯氧乙酸甲酯的制备 12