年产500吨扑热息痛的生产工艺设计
毕业论文关键字：扑热息痛；对氨基苯酚；对乙酰氨基酚；工艺设计
Abstract
Acetaminophen, also known as paracetamol, it is one of the most commonly used drugs for the heat, pain, and colds. With the development of modern technology, the production process of anti-inflammatory drugs are constantly improving.There are many synthetic methods of acetaminophen, acetaminophen can be prepared according to the method of producing PAP and APAP whether it’s independent pided into one-step and two-step method, but there are some problems such as, complex process, low yield, high energy consumption and high cost. This design involves a kind of synthesis of acetaminophen, especially involving the process method of using the nitro phenol as a starting material, synthesis of acetaminophen(APAP) by palladium/carbon hydrogenation and acetylation. The production solutions are as follows: we use the nitro phenol as raw materials, supported palladium/carbon catalyst with hydrogen catalytic to synthesis of paracetamol, using acetic anhydride to acylated to prepare APAP. Compared with prior art, it’s a higher selectivity for PAP, simplifying the existing production process, increase yields, reducing energy consumption, saving costs and reducing waste generation.
Keywords: acetaminophen; p-aminophenol; acetaminophen;Process Design窗体底端
目录
摘 要 I
Abstract II
第一章 课题背景 1
1.1 课题来源 1
1.2 研究背景及意义 1
第二章 文献综述 2
2.1 引言 2
2.2 生产工艺路线比较 2
2.2.1 以苯酚为原料合成扑热息痛 2
2.2.2 以硝基苯为原料的合成路线 3
2.2.3 以对硝基苯酚钠为原料的路线 5
2.2.4 其他合成路线 5
2.2.5 本设计采用的合成路线 5
2.3 生产规模的确定 6
第三章 产品方案 7
3.1 产品名称与性质 7
3.2 性状及理化性质 7
3.3 产品的质量规格 7
3.4 产品的生产制度 7
3.5 包装与储藏 7
第四章 生产方法与主要工艺流程 8
4.1 生产方法 8
4.2 主要工艺流程 8
4.3 工艺过程说明 8
4.3.1 PAP的制备 8
4.3.2 APAP的初制 9
4.3.3 APAP的精制 9
第五章 生产工艺控制和中间体质量标准 10
5.1 生产工艺控制 10
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