温敏性PNIPAAM传感器的制备研究
毕业论文关键词 聚 N-异丙基丙烯酰胺 温敏性 光聚合 微流控液滴技术
Title Miniaturization PNIPAAM Sensor Preparation Research
Abstract Thermo-sensitive functional polymer materials are getting paramounting importance in recent years. PNIPAAM as an example, gets warm attention because its Lower Critical Solution Temperature (short for LCST) is 32℃, which life can prosper. Thus, it is especially applicable for bio-related systems and processes. Intensive researches have been taken based on the specialty of PNIPAAM, which have led to its success and wide applications in fields like drug release, enzyme immobilization, mathematical analysis, flocculating agent, nano reactor. Here we combine UV polymerization with microchip droplets technology to generate PNIPAAM. On this chip, PNIPAAM droplets can be prepared continuously with high uniformity. By tuning the droplet generation conditions, their sizes and thermo-sensitivity can be achieved.
Keywords PNIPAAM thermosensitivity photopolymerization microchip droplets technology
目录
1 引言 1
2 实验部分 8
2.1 仪器 8
2.2 试剂 8
2.3 N-异丙基丙烯酰胺单体混合液溶液的制备 8
2.4 N-异丙基丙烯酰单体混合液液滴制备 8
2.5 聚N-异丙基丙烯酰胺微球的光固化 9
2.6 聚N-异丙基丙烯酰胺微球的分离 . 11
2.7 聚N-异丙基丙烯酰胺微球的温敏性测试 . 11
3 实验结果与讨论 12
3.1进样流速比对液滴的影响因素 12
3.2 N-异丙基丙烯酰胺微球性能表征的光固化 . 13
3.3聚N-异丙基丙烯酰胺微球性能表征 . 13
3.2.1微球温敏性体积随交联剂配比的变化 13
3.2.2温敏性微球体积随时间的变化 18
4 结论 20
5 致谢 21
6 参考文献 22
1 引言 功能性高分子材料通常是形容可以贮存、传达以及转变能量、物质和信息的高分子材料。而其中温敏性高分子材料由于其温度响应性能较好，应答模式容易观察被科研工作者广泛关注。聚-N异丙基丙烯酰胺是一种温敏性材料，当位于某一特定温度（该温度又被称为高分子材料的最低共溶温度或会溶温度）时，可以迅速发生可逆相变，由于这一温度一般在 32℃左右[1]，处于生物活体温度范围内而备受青睐。利用这一特征，可以实现聚Ｎ－异丙基丙烯酰胺在生物药物释放、固定化酶、免疫分析、絮凝剂和纳米反应器等方面进行广泛应用。一般传统聚合制备聚 N-异丙基丙烯酰胺温敏性微球的办法有微乳液聚合法和共沉淀法等等。除此之外，本文采用了微流控液滴技术结合光聚合原理方法[2]实现温敏性微球的制备。
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