摘要:生活中的流感病毒往往会引发人们急性呼吸道感染，对人类身体的健康产生了严重的威胁。神经氨酸酶是在病毒入侵及预防中起着非常大的作用，使用神经氨酸酶抑制剂就是抑制病毒的有效方法。从近代医学的角度来说，神经氨酸酶抑制剂是以神经氨酸酶为起点的药物，它能够快速有效的抑制流感病毒的自我复制，是现在比较常用的一种医用药。本文主要研究开发新型的神经氨酸酶抑制剂合成中第一步骤的原料配比，如肉桂醛，苯甲醛，吡啶-3-甲醛等的底物，根据不同比例的反应得到产物的不同产率，找到最合适的反应点，为后面步骤提供原料。52690

毕业论文关键字　流感病毒；神经氨酸酶；抑制剂；底物

Study on Synthesis of the new neuraminidase inhibitors

Abstract:  Influenza viruses in life tend to cause people with acute respiratory infections, the health of the human body has a serious threat. In the virus intrusion and prevention plays a very big role, neuraminidase inhibitors is to suppress the virus neuraminidase is an effective way. From the point of view of modern medicine, the neuraminidase inhibitors is to neuraminidase is the starting point of the drug, which can quickly and effectively inhibit influenza virus self replication, it is now more commonly used a kind of medicine. In this paper, the main research and development of new neuraminidase inhibitors in the synthesis of the first step of the ratio of raw materials,Such as the substrate of the cinnamon aldehyde, the benzene formaldehyde, the pyridine -3- formaldehyde and so on, according to the different proportion of the reaction product of different yield, to find the most appropriate response, for the following steps to provide raw materials.

Keywords：influenza virus；Neuraminidase；inhibitor；substrate

目  录

1 前言 1

1.1NA药物研究及其意义 1

1.1.1 NA药物扎那米韦 1

1.1.2 NA药物奥赛米韦 2

1.1.3 NA药物帕拉米韦 2

1.2 NA抑制剂概述及其分类 2

1.2.1 神经氨酸类似物 3

1.2.2 环乙烯类 3

1.2.3 环戊烷类 4

1.2.4 苯甲酸类 4

1.2.5 吡咯环类 4

1.2.6 吲哚生物碱类 5

    1.3 NA抑制剂的发展 5

    1.4 NA抑制剂的设计原理 5

    1.5神经氨酸酶抑制剂的合成过程 9

    1.6 研究目的和意义 10

2 实验部分 11

2.1 试剂与材料 11

2.2 仪器设备 11

2.3 分析步骤 11

2.3.1 反应 11

2.3.2 后处理及提纯 13

2.3.3 测定产物 13

       2.3.4其他反应14 2.4 结果与分析 18

3 结论 19

致谢 20

参考文献 21 

1 前言