具有催泪活性的化合物的合成研究
本论文以苯乙酮为测试底物，与毒性小、价格便宜的氯代试剂三氯异氰尿酸（TCCA）反应，并使用苄基三乙基氯化铵（TEBAC）作为催化剂，优化反应条件，尝试发展绿色、高效的氯代化合物合成路线。通过优化的实验条件是：苯乙酮的量为1.20 g，三氯异氰尿酸的量为1.55 g，苄基三乙基氯化铵的用量为0.30 g，在室温条件分3次加入下搅拌反应30 min，α，α-二氯代苯乙酮的产量为1.76 g，产率为92.1%。在优化条件的基础上，将苯乙酮类化合物作为测试底物时发现，二氯代物的产率在73.2% ~ 93.5%之间，产率相对较高的是苯乙酮（92.1%），对甲基苯乙酮（93.5%）。
毕业论文关键词： 二氯代苯乙酮；绿色化学；无溶剂反应
The study of synthesis of lachrymatory compound
Abstract: Since the traditional chemical industry brings more and more serious the environment pollution, people realize the importance of protecting the environment. So people put forward the concept of green chemistry. In recent years, people are paying more and more attention to environmental protection, so it is necessary to carry out green chemistry. Chlorination of phenyl ethyl ketone compounds are important intermediates in organic synthesis, although there are many methods to synthesize these compounds, these methods have the following disadvantages, such as long reaction time,using toxic reaction reagent,post-processing of trouble and so on, which do not conform to the concept of green chemistry. Therefore, it is necessary to research done in solvent-free catalytic non-toxic harmless rapid response.
This thesis is trying to optimize the reaction condition that using acetophenone as the substrate reacted with trichloroisocyanuric acid, which is cheap and low toxicity under using triethylbenzylammonium chloride as catalyst, then trying to develop the green and efficient synthetic route of chloride. The optimized experiment condition was: at the temperature, acetophenone, which quality was 1.20 g and trichloroisocyanuric acid, which quality was 1.55 g were mixtured with triethylbenzylammonium chloride, which quality was 0.30 g, to stir for 30 min. Besides, triethylbenzylammonium chloride was pointed three times to join. The yield of α，α-dichloro phenylethanone was 92.1%. On the basis of the optimized conditions, when acetophenones were used as the substrate, the yield of chlorination were between 73.2% and 93.5%. Acetophenone and p-methylacetophenone were in high yield (92.1%, 93.5%).
Key words: chlorination acetophenone; green chemistry; solvent-free reaction
目 录
1 绪论 1
1.1 催泪化合物的性质和用途 1
1.1.1 催泪化合物的性质 1
1.1.2 催泪化合物的制备 1
1.2 无溶剂反应的重要性 2
1.2.1 室温下无溶剂反应的应用 2
1.2.2 加热下无溶剂反应的应用 4
1.2.3 微波辐射下无溶剂反应的应用 5
1.3 本论文的研究意义 7
2 具有催泪活性的化合物的合成研究 8
2.1具有催泪活性的化合物的最佳条件探索 8
2.1.1 结果与讨论 8