年产500吨5氯2羟基苯乙酮的工艺设计(2)
3.设计原则及主要设计指标
原则： (1) 安全：化工生产中大量物质是易燃、易爆或者有毒性的。因此，设计必须充分考虑各种明显的和潜在的危险，保证生产人员的健康和安全。
（2） 操作方便：在确定各个生产过程及设备的同时，还要合理确定操作条件。因为它对生产过程与设备的确立及其作用的发挥和控制方案的确定，都有直接关系。
（3） 投资省：即要求经济地使用设备投资、土建投资、公用工程投资和人力成本。
(4) 便于安装：工厂布置应满足施工和安装作业要求。特别是应考虑大型设备的吊装，厂内道路的路面结构和载荷标准等应满足施工安装的要求。
关键词：5-氯-2-羟基苯乙酮；4-氯苯酚；设计；反应釜
Instruction manual:
Project: The workshop Design of 500 ton 5-Chloro-2-hydroxyacetophenone yield yearly
Pranlukast is the world's first leukotriene receptor antagonist, is the pioneered by Ono Pharmaceutical Co. Ltd. in Japan, the first time in 1995 in Japan, mainly used in clinical treatment of allergic rhinitis andasthma. Pranlukast efficient role in a wide range low toxicity, adverse reactions, listed from the soon occupied the anti-asthma drug market, become the most talked about in the international market leukotriene receptor antagonist one of the agents.
At present, China has just started for pranlukast synthetic research, an important intermediate 2 - hydroxy-3 - aminoacetophenone the market demand is on the rise. On the intermediate bulk synthesis of few reports on the market 2 - hydroxy-3 - amino-acetophenone of higher prices, is far from meeting the needs of the market. Therefore, to find a low-cost, environmental protection, high yield, and suitable for industrial production of 2 - hydroxy-3 - the synthetic route aminoacetophenone has very important significance.
The conventional synthetic pranlukast process of 3 - amino-2 - hydroxyacetophenone and 4 - phenyl-O-butane hydrochloride as a starting material, the ether-forming, acid amines, Clay-condensation, ammoniated,cyanide formed with NaN3 addition to the formation of tetrazolium reaction to get the pranlukast. This paper is to study the synthesis of 3 - amino-2 - hydroxyacetophenone key intermediate 5 - chloro -2 - hydroxy-ethanone was prepared. This route is similar to the other routes, but also improved the yield and purity of the final product are greatly improved, compared with other routes, conducive to the final purification. Process design, to enable it to large-scale production.
Along with the chemical industry fast development, the chemical product already the omnipresent there is no place did not have. Therefore the chemical design duty is more and more heavy. First, in the chemical production, through transporting chemical industry design aspect knowledge and the method, may realize to the chemical factory (workshop) rebuilding and extension, carries on the productivity to the unit operation equipment or the entire installment to demarcate with the technology economic indicator evaluates; carries on the appraisal to the technical process; discovers the weak link and unreasonable phenomenon as well as excavation productive potential and so on. Second, in scientific research, since childhood experimental to experimental enlargement, down to the investment industrial production, all cannot leave the design. Looked from the modern times photochemistry industrial development process that, the research holds the important status day by day. But if we want cause the scientific research achievement to transform the productive forces, namely realizing industrialization, We must carry on the scientific research and design in close integration with new development work and so on craft, new product as well as new equipment. Third, in the capital construction, design is the capital construction most important link, is the ready-made construction basis. From single equipment to complete set installment, from a miniaturized factory (workshop) to large-scale petroleum chemical industry enterprise, they all must first finish the engineering design before construction. If we want to complete a good quality and advanced level chemical industry installment, the important precondition is must have a high level and high grade design. Enhanceing the design’s quality and speed is the crucial promoter action to the capital construction enterprise development.