Baeyer-Villiger反应δ-十二内酯的合成+文献综述
关键词 Baeyer-Villiger反应 过氧化氢 δ-十二内酯 过渡金属
毕业论文设计说明书外文摘要
Title Synthesis of δ-dodecalactone
Abstract
As a green oxidation,hydrogen peroxide is environmentally-friendly and clearn ,which has been increasingly popular in organic synthesis.In this paper,we will introduce fragrance and flavours and design experiments according to these knowledge.what’s more,we also have a general description about the reasearch history and present state of the Baeyer-Villiger in detail. To learn more about the mechanism and to improve the conversion of the Beayer-Villiger oxidation reaction, avoiding environmental problems peracid brings, we will carry on experiments by using hydrogen peroxide as oxidations,transition metals as catalyst to oxidate 2-heptylcyclopentanone into δ-dodecalactone.The experiment indicate that the prime reaction conditions are 0.55g 2-heptylcyclopentanone and 0.4ml（2.5eq）hydrogen peroxide（50%） separately， 0.06 g WoO3 as catalyst reacting 12h at 40℃；the conversion can up to 98.7% and the yield rate is 79.2% . Some factors have great influence on the reaction,such as the polarity of solvent , the amount of catalyst, the amount and concentration of hydrogen peroxide,reaction temperature and time .All these factors have been designed .All results will show in this dissertation .（Shimadzu GC一2014C） gas chromatography will used as instrument to analyze the conversion of 2-heptylcyclopentanone and the yield ofδ-dodecalactone .And the foremost acid byproduct:5-oxours-dodecanoic was isolated and identified by 1H-NMR.
Keywords Baeyer-Villiger reaction 2-heptylcyclopentanone hydrogen peroxideWoO3
目 次
1引言 1
1.1 香精与香料 1
1.2 Baeyer-Villiger反应 2
2 实验部分 15
2.1 原料与产物的理化性质 15
2.2 实验试剂与实验设备 15
2.3 实验装置与实验过程 16
3 不同条件对Baeyer-Villiger反应的影响 18
3.1 不同催化剂催化的Baeyer-Villiger反应 18
3.2 不同质量MoO3催化的Baeyer-Villiger反应 19
3.3 不同温度下的Baeyer-Villiger反应 19
3.4 不同反应时间下的Baeyer-Villiger反应 20
3.5 不同溶剂下的Baeyer-Villiger反应 21
3.6 不同浓度H2O2下的Baeyer-Villiger反应 21
3.7 不同量的H2O2溶液下的Baeyer-Villiger反应 22
4 实验结果分析 23
4.1 理论产物分析 23
4.2 实际产物分析 23
4.3 催化Baeyer-Villiger反应的机理分析 24
5 总结 26
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